The different kinds of Antidepressants (A-Z) available?

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This blog post will explore the various Antidepressants available in the UK and the US in alphabetical order from A-Z. 

We will also briefly discuss what antidepressants are, the different kinds of Antidepressants, what it is used for, and it’s side effects

What are the different kinds of Antidepressants (A-Z) available?

The different kinds of Antidepressants that have been approved for use to treat depression related symptoms as well for other mental disorders, in alphabetical order from A-Z, include:

In the United States, the approved list of antidepressants referred from the compiled list as provided by Web.MD  include:


  • Abilify (aripiprazole) – an antipsychotic medication used in combination with an antidepressant
  • Adapin (doxepin)
  • Anafranil (clomipramine)
  • Aplenzin (bupropion)
  • Asendin (amoxapine)
  • Aventyl HCI (nortriptyline)


  • Brexpiprazole (Rexulti) – an antipsychotic medication used in combination with an antidepressant”


  • Celexa (citalopram)
  • Cymbalta (duloxetine)


  • Desyrel (trazodone)


  • Effexor XR (venlafaxine)
  • Emsam (selegiline) 
  • Esketamine (Spravato) 
  • Etrafon (perphenazine and amitriptyline)
  • Elavil (amitriptyline)
  • Endep (amitriptyline)


  • Fetzima (levomilnacipran)


  • Khedezla (desvenlafaxine)


  • Latuda (lurasidone) 
  • Lamictal (lamotrigine)
  • Lexapro (escitalopram)
  • Limbitrol (amitriptyline and chlordiazepoxide)


  • Marplan (isocarboxazid)


  • Nardil (phenelzine)
  • Norpramin (desipramine)


  • Oleptro (trazodone)


  • Pamelor (nortriptyline)
  • Parnate (tranylcypromine)
  • Paxil (paroxetine)
  • Pexeva (paroxetine)
  • Prozac (fluoxetine)
  • Pristiq (desvenlafaxine)


  • Remeron (mirtazapine)


  • Sarafem (fluoxetine)
  • Seroquel XR (quetiapine)
  • Serzone (nefazodone)
  • Sinequan (doxepin)
  • Surmontil (trimipramine)
  • Symbyax (fluoxetine and the atypical antipsychotic drug olanzapine)


  • Tofranil (imipramine)
  • Triavil (perphenazine and amitriptyline)
  • Brintellix (vortioxetine)


  • Viibryd (vilazodone)
  • Vivactil (protriptyline)


  • Wellbutrin (bupropion)


  • Zoloft (sertraline)
  • Zyprexa (olanzapine) 

In the UK, the following list compiled by Uk, is the list of approved antidepressants used:


  • agomelatine
  • Allegron (see nortriptyline)
  • Alventa XL (see venlafaxine)
  • Amphero XL (see venlafaxine)
  • Amitriptyline


  • Brintellix (see vortioxetine)


  • Cipralex (see escitalopram)
  • Cipramil (see citalopram)
  • citalopram
  • clomipramine
  • Cymbalta (see duloxetine)


  • Depefex XL (see venlafaxine)
  • dosulepin
  • doxepin
  • duloxetine


  • Edronax (see reboxetine)
  • Efexor XL (see venlafaxine)
  • escitalopram


  • Faverin (see fluvoxamine)
  • fluoxetine
  • fluvoxamine
  • Foraven XL (see venlafaxine)


  • imipramine
  • isocarboxazid


  • lofepramine
  • Lomont (see lofepramine)
  • Lustral (see sertraline)


  • Majoven XL (see venlafaxine)
  • Manerix (see moclobemide)
  • mianserin
  • mirtazapine
  • moclobemide
  • Molipaxin (see trazodone)


  • Nardil (see phenelzine)
  • nortriptyline


  • Olena (see fluoxetine)
  • Oxactin (see fluoxetine)


  • Parnate (see tranylcypromine)
  • paroxetine
  • phenelzine
  • Politid XL (see venlafaxine)
  • Prothiaden (see dosulepin)
  • Prozac (see fluoxetine)
  • Prozep (see fluoxetine)


  • reboxetine


  • Seroxat (see paroxetine)
  • sertraline
  • Sinepin (see doxepin)
  • Sunveniz XL (see venlafaxine)
  • Surmontil (see trimipramine)


  • Tonpular XL (see venlafaxine)
  • tranylcypromine
  • trazodone
  • trimipramine


  • Valdoxan (see agomelatine)
  • Venladex XL (see venlafaxine)
  • Venaxx XL (see venlafaxine)
  • Vencarm XL (see venlafaxine)
  • Venlablue XL (see venlafaxine)
  • venlafaxine
  • Venladex XL (see venlafaxine)
  • Venladex XL (see venlafaxine)
  • Venlalic XL (see venlafaxine)
  • Vensir XL (see venlafaxine)
  • ViePax XL (see venlafaxine)
  • vortioxetine


  • Zispin (see mirtazapine)

What are Antidepressants?

Antidepressants are medications that were first developed in the 1950s that are used to help treat symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.

Antidepressants work to correct chemical imbalances in the brain- chemicals known as neurotransmitters that are responsible for changes in mood, behaviour, and emotions. 

By correcting and balancing the levels of these chemicals in the brain in various ways, these medicines can help improve your mood, bring positive changes related to various symptoms such as focus and concentration, sleep, appetite etc.

What are the different types of Antidepressants?

Antidepressants are of different classes or different types depending on their target and the process by which they help balance neurochemical levels in the brain. 

The different classes of antidepressants are as follows:

Selective serotonin reuptake inhibitors (SSRIs) 

These are the most commonly prescribed antidepressants because of their high levels of efficacy and low number of side effects. 

These drugs help to increase levels of serotonin in the brain by inhibiting reuptake of these chemicals by blocking the receptors. 

As SSRIs affect the levels of serotonin and not other neurotransmitters, they are referred to as “selective.”

The use of this class of antidepressants commonly involve a few side effects such as nausea, vomiting, diarrhea, sexual dysfunction, headache, weight gain, anxiety, dizziness, dry mouth, and trouble sleeping.

One might also experience abnormal bleeding if it is used with painkillers and blood thinners. Some might also be affected by Serotonin syndrome which is a serious medical condition with symptoms such as anxiety, restlessness, sweating, muscle spasms, shaking, fever, rapid heartbeat, vomiting, and diarrhoea that occur when SSRIs are used with other medication. 

It is also obersevered that antidepressants such as SSRIs may also increase the risk of suicidal thoughts or behavior in children, adolescents, and young adults (18 to 24 years of age).

Serotonin norepinephrine reuptake inhibitors (SNRIs) 

This particular medication works by blocking the reabsorption of the neurotransmitters serotonin and norepinephrine in the brain so as to increase the levels of these neurotransmitters. 

The difference between SSRIs and SNRIs is that SNRI is not selective and may influence the levels of other neurotransmitters. 

The common side effects of SSRIs include nausea, dizziness, and sweating as well as sexual dysfunction. Other less serious side effects include tiredness, constipation, insomnia, anxiety, headache, and loss of appetite.

Significant and serious side effects also include abnormal bleeding when used wiht other drugs and blood thinners as well as increase in the rates and the risk of suicidal thoughts or behavior in children, adolescents, and young adults (18 to 24 years of age).

Some SNRIs should also not be used by people who are affected with uncontrolled narrow angle or angle-closure glaucoma.

Tricyclic antidepressants (TCAs) 

TCAs are drugs that block the reabsorption of Serotonin and norepinephrine in the brain and they were the first approved drugs for depression however as of today, more efficient drugs are used that has less side effects as compared to TCAs.

TCAs affect several neurotransmitters in the brain and are neither selective nor does it influence only serotonin and norepinephrine and because of its impact on many neurotransmitters it causes any side effects which render it less efficient than other classes. 

Side effects of this drug include dry mouth, constipation, blurred vision, urinary retention, dizziness, tachycardia, memory impairment, and delirium, orthostatic hypotension, weight gain, seizures, bone fractures, sexual dysfunction, increased sweating, and increased or irregular heartbeats.

Monoamine oxidase inhibitors (MAOIs) 

MAOIs are drugs that work by blocking or inhibiting the activity of monoamine oxidase which is crucial in the breakdown of norepinephrine, serotonin, and dopamine in the brain and other parts of the body. 

This drug is not a primary option that many physicians prescribe because it has many drug and food interactions and also causes significant side effects. As a result, this class of drug has been replaced by newer antidepressants that are safer and cause fewer side effects.

Common side effects of this class of drugs include postural hypotension, weight gain, and sexual side effects as well as various food and drug reactions.

MAOIs with tyramine-containing foods or beverages may cause dangerous elevations in blood pressure.

Foods such as wine, aged cheese, sauerkraut, cured meats, draft beer, soy products should also be avoided and this particular drig also elevates the risks of Suicidal thoughts or behavior in children, adolescents, and young adults (18 to 24 years of age).

Atypical antidepressants

This type of drugs do not fit into any of the other classes of antidepressants and each drug under this category has unique mechanism with which it affects  the body. 

However, atypical antidepressants also affect the levels of dopamine, serotonin, and norepinephrine in the brain. 

Since medications in this class are all unique in their effect on the body, their side effects also vary. Some common side effects include dry mouth, constipation, dizziness, and lightheadedness.

Some of these drugs can cause abnormal heart rhythms that can be life threatening as well as cause a rare sexual disorder that involves painful and prolonged erection in males.

Some of these drugs are also not recommended in patients with active liver disease and it can increase the likelyhood of Suicidal thoughts or behavior. 

What are the uses of Antidepressants?

Antidepressants are primarily used to treat depression and depression realted symotoms however, these medications are used not only to treat depression but for other conditions too.

Some of the conditions that these drugs have been approved for include:

  • agitation
  • obsessive-compulsive disorders (OCD)
  • childhood enuresis, or bedwetting
  • depression and major depressive disorder
  • generalised anxiety disorder
  • bipolar disorder
  • posttraumatic stress disorder (PTSD)
  • social anxiety disorder

Other “Off-Label” uses where the drug has not been approved for certain uses and conditions but tend to be effective include:

  • insomnia
  • pain
  • migraine

What are the side effects of Antidepressants?

Common side effects of Antidepressants include:

  • Gastrointestinal symptoms such as indigestion, diarrhoea, constipation, loss of appetite
  • Headache, dizziness, dry mouth, sweating
  • Agitation, shakiness, nervous feeling
  • Palpitations, fast heartbeat
  • Blurry vision
  • Unexpected weight loss or weight gain
  • Sexual dysfunction and low libido
  • Insomnia


This blog post has explored the various Antidepressants available in the UK and the US in alphabetical order from A-Z. 

We have also briefly discuss what antidepressants are, the different kinds of Antidepressants, what it is used for, and it’s side effects

FAQ related to Antidepressants: A to Z

What depression medication starts with Z?

Some of the depression medications that start with the letter Z include:

  • Zelapar.
  • Zoloft.
  • Zoloft.
  • Zoloft.
  • Zyban.
  • Zyprexa.

What are the top 10 antidepressants?

Top 10 Antidepressants based on Prescription rates and Sales include:

  • Viibryd.
  • Celexa.
  • Zoloft.
  • Prozac.
  • Desyrel.
  • Lexapro.
  • Paxil.
  • Effexor.

What is the #1 antidepressant?

The number one Antidepressant on the market is Zoloft. It is the most commonly prescribed antidepressant.

What is the hardest antidepressant to come off of?

Some of the hardest antidepressants that users find difficult coming off of or stopping include:

  • citalopram (Celexa)
  • escitalopram (Lexapro)
  • paroxetine (Paxil)
  • sertraline (Zoloft)

What is the newest and best antidepressant?

Esketamine is a new antidepressant drug approved by the FDA in 2019 to treat depression that is resistant to treatment and that which has not improved with other pharmacological interventions and medications. The drug is part of a class of medications called N-methyl D-aspartate (NMDA) receptor blockers. 


Antidepressants A–Z. Retrieved on 6th january 2022.

Cherney.L.What Medications Help Treat Depression?. Healthline. Retrieved on 6th January 2022.

Depression Medications (Antidepressants). WebMD. Retrieved on 6th January 2022.

Nordqvist.C. All about antidepressants. Medicalnewstoday. Retrieved on 6th January 2022.


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