Can I take Tylenol with prednisone?

Can I take Tylenol with prednisone?

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The current blogspot will be based on the question Can I take Tylenol with prednisone?

We will discuss the drug interactions between tylenol and prednisone. We will also learn the adverse effects of taking tylenol with prednisone.

Can I take tylenol with prednisone?

Yes, tylenol and prednisone can be taken together.

Tylenol is  a brand name for the chemical acetaminophen. Tylenol is used as an effective pain killer. It works by increasing the threshold of the individual. Tylenol works to reduce pain by keeping the brain from releasing pain signals. It also has a tendency to act upon the hypothalamus to reduce the fever and body heat.

Tylenol is a drug of choice for reducing pain in the common cold, menstrual cramps, back ache, muscle ache, toothache and fever.

Prednisone is a steroid based glucocorticoid. It is based on hydrocortisone and cortisone. Prednisone works by lowering the immune system and thus preventing inflammation and pain related to rheumatoid arthritis.

Prednisone is used to treat various autoimmune diseases that occur when the autoimmune system attacks healthy body cells.

Prednisone is known to treat a number of conditions known as : 

  • Blood disorders including Autoimmune hemolytic anemia, congenital hypoplastic anemia, leukemia, and lymphoma
  • Skin diseases including  Atopic dermatitis (eczema), severe psoriasis, and Stevens-Johnson syndrome
  • Endocrine disorders including  Addison’s disease and congenital hyperplasia
  • Eye-related allergic reactions including Conjunctivitis (pink eye), keratitis (cornea inflammation), and optic neuritis (inflammation damaging the optic nerve)
  • Rheumatic disorders including Gout, epicondylitis (tennis elbow), multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus

Taking tylenol with prednisone is considered safe as to date no drug interactions have been reported and no research studies confirm the adversities caused by combining Tylenol drug with prednisone drug. However, it is always advisable to consult your physician to check for any conditions that need to be monitored or any precautionary measures that need to be taken before starting the treatment based on the interaction of Tylenol with prednisone.

What are the effects of tylenol and prednisone on the human body?

Tylenol is based on salt acetaminophen. Large doses of Tylenol can lead to :

  • Liver damage due to dose exceeding then 3250mg within 24 hours in adults
  • Individuals taking blood thinning agents should not take tylenol without prescription of a doctor
  • Tylenol can cause severe skin reactions to people who are allergic to acetaminophen.

Prednisone is a corticosteroid is known to produce the following effects on our body:

  • Prednisone lowers immune function when taken in large dose
  • Prednisone increases a person’s susceptibility to infection
  • Prednisone masks severe infections among individuals
  • Prednisone use in tuberculosis needs special supervision  regarding the drug’s potential in reactivating the disease
  • Prednisone causes hypertension
  • Prednisone leads to salt and water retention in body
  • Prednisone results in increased excretion of potassium and calcium from our body
  • Prednisone if stopped abruptly often leads to withdrawal symptoms.
  • Prednisone leads to thinning of bone
  • Prednisone leads to mood alterations
  • Prednisone causes stomach issues leading to indigestion
  • Prednisone leads to weight gain
  • Prednisone leads to trouble breathing
  • Prednisone impairs judgment abilities
  • Prednisone impairs an individual’s executive functioning
  • Prednisone may lead to restlessness and psychomotor agitation


The current article was based on the question ”can we take Tylenol with prednisone? ”We discussed the drug combination of Tylenol and prednisone and how Tylenol and prednisone have effects on our body.

Frequently asked questions : can I take tylenol with prednisone?
What pain reliever can be taken with prednisone?

Tylenol can be taken as a pain reliever with prednisone as no drug interactions have been reported.

Can I take Tylenol with prednisone?

It is usually considered safe to take tylenol with prednisone. There have been no studies to confirm any drug interactions. However it is always better to consult your doctor before taking any medicine.

Can I take extra strength Tylenol with steroids?

There have been no reports of any drug interactions between Tylenol with steroids and prednisone. However, it is always safe to consult your medical practitioner before starting medicine in combination with any other drug.

What medicines should not be taken with prednisone?

Using nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and salicylates such as aspirin may increase the risk of toxicity and gastrointestinal side effects when taken with prednisone.
Should I drink more water while taking prednisone?
Fluid retention can cause weight gain but as steroids are reduced, fluids will usually reduce as well, along with some of the weight gain. Drinking plenty of water and exercising can help with fluid retention.
Can I take Advil or Tylenol with prednisone?

As compared to Advil which is based on ibuprofen, Tylenol is safer to use with prednisone due to no drug interactions between Tylenol and prednisone.


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