Can you take Kalms with other medications?

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This blog post will explore the question of whether you can take Kalms with other medications.

We will also briefly discuss what Kalms is, what it is used for, the different kinds of kalms and the key ingredients used in Kalms and it’s side effects, as well as other risks and precautions when taking the drug. 

Can you take Kalms with other medications?

While it is possible for you to take other medications with Kalms, it is highly and strictly mentioned that you must consult with a physician before you add the use of Kalms with other medications.

This is because it is possible that they key active ingredients of Kalms- specifically Valerian root, hop strobiles which are flowers of the hop plant Humulus lupulus, and extract of Gentian root- can react with other drugs and food.  

While one might think that because Kalms is made with herbal ingredients that the interaction will not occur or might be benign, it is possible that drug and food interactions with Kalms, as well as other herbal medications can lead to severe issues. 

In an article for Time, Amanda Macmillan explored the herbal medication and prescription drug interaction based on a clinical trial published in the British Journal of Clinical Pharmacology. 

Macmillan noted this particular trial and review found that there are cases where there has been 51% average probably for interaction between the two classes of medications for various herbal drugs with pharmacological treatments for heart disease, cancer or kidney transplants.

While this article nor the research explores the interactions of the key ingredients in Kalms, there have been multiple researchers that debate the significant interactions of Valerian, the key ingredient in kalms, and other drugs. 

One particular review, that explored the clinical significance of Valerian to anticancer drugs included that the interaction effects were not significant to cause alarm.

However, the findings of this review cannot be generalised to other medications. In another review it has been noted that there is a potential interaction with drugs such as barbiturates, anaesthetics, narcotics, and other central nervous system depressants.

Interactions with these drugs might increase the effects of severe drowsiness as a result of interaction between the sedatives in these drugs. 

So it is possible that Calms might have some interaction with Barbiturates, anaesthetics, and other depressants due to their interactions with Valerian extract, the key ingredient. 

What are the various drug/food interactions of Kalms?

The various food and drug interactions that occur with Kalms tablets include:

Sedatives and Kalms should not be used together as it can increase the effect of the sedatives present. Sedatives that should be avoided include:

  • Anticonvulsants such as phenytoin (Dilantin) and valproic acid (Depakote)
  • Barbiturates
  • Benzodiazepines such as alprazolam (Xanax) and diazepam (Valium)
  • Drugs to treat insomnia, such as zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Lunesta), and ramelteon (Rozerem)
  • Tricyclic antidepressants such as amitriptyline (Elavil)

Other drugs that could risk interactions include those drugs that are also broken down by the liver enzymes such as:

  • Antihistamines
  • Statins (drugs taken to lower cholesterol)
  • Some antifungal drugs

It is also possible that Valerian can increase the effects of anaesthesia thus, it is advisable that the doctors are informed of the use of Kalms before use of anaesthesia for any surgery or procedures. 

Alcohol (Ethanol) can cause increased sleepiness and drowsiness when used with valerian as well as the drug Alprazolam (Xanax).

Sedative medications (CNS depressants)when used with valerian  might cause sleepiness and slowed breathing or other breathing problems. 

What is Kalms?

Kalms Tablets are traditional natural drugs designed for relief of signs associated with:

  • Stress (e.g mild anxiety, worry, irritability)
  • Menopause (e.g flushings, worry, wakefulness, cold sweats)
  • Sleeping problems, promoting natural sleep

It is important that before you use the tables to ask your doctor or pharmacist if you can take Kalms tablets when taking other prescription medicines or medicines without a prescription.

What is Kalms made of?

The Kalms tablet’s ingredients tend to differ according to the kind of Kalms tablet that is being referred to by the key ingredients of Kalms is Valerian root, hop strobiles which are flowers of the hop plant Humulus lupulus, and extract Gentian root.

  • Valerian (Valeriana officinalis) is an herb found originally in Europe and parts of Asia and is known for its sedative effects on the brain and nervous system. 

Valerian has been used as a traditional medicine dating back to ancient Greeks and is commonly used to manage insomnia and sleep disturbances. 

Valerian may also be used for anxiety and stress, however there is not enough scientific evidence to support its use. 

Some common side effects of this herb include dizziness, drowsiness, headache, stomach upset, mental dullness, and vivid dreams. 

  • Gentian root is derived from the Gentiana genus, a flowering plant found in the highlands in parts of Europe, Asia, and the Americas. Though the flower of the plant is beautiful, only it’s roots are used for medical purposes. 

The root is usually dried and made into pills, teas, tinctures, and extracts and either topically applied with a plaster or consumed as a drink.

  • Hops are the dried, flowering parts of the hop plant (Humulus lupulus), commonly used as a medicinal plant for various remedies; however, evidence of health benefits is limited. 

Hops contain many chemicals that seem to act similarly to the hormone oestrogen while other chemicals in the plant seem to cause sleepiness.

Here are the descriptions of the key ingredients used in Kalms tablets:

Kalms Night One-A-Night

The active Ingredient of this kind of Kalms Tablet is Dry Extract from Valerian Root (Valeriana Officinalis L.) along with  Ethanol 60% V/V 385mg as the solvent. 

Kalms Night

The active substance per tablet is Dry extract from Valerian root – 96 mg, (Valeriana officinalis L.) with Ethanol 60%v/v as the solvent.

The other ingredients include Croscarmellose Sodium, Magnesium Stearate, Silicified Microcrystalline Cellulose, Talc and Silicon Dioxide in the core while the Coating of the tablet contains Hypromellose, Talc, Titanium Dioxide, Macrogol, Saccharin Sodium.

Kalms Day

Active Ingredients of the day tablet is 33.75mg of Dry Extract from Valerian Root (Valeriana Officinalis L.) and Ethanol 60% v/v, along with Sucrose.

Kalms Lavender One-A-Day Capsules

Active Ingredients is 80 mg of oil from flowering tops of Lavender (Lavandula angustifolia Miller, aetheroleum) and also contains Sorbitol. 

Kalms Lavender One-A-Day capsules are the only type of Kalms tablet that has Lavender instead of Valerian as the main component. 

What are the side effects of Kalms?

Even though this is considered a natural and herbal remedy. Valerian root and other herbal remedies can cause side effects. 

While not everyone will experience the same side effects or effects of the medication, it is important to be aware of the reactions it might cause. 

Side effects include:

  • Gastrointestinal effects such as nausea and stomach cramps.
  • Gastrointestinal disorders have been observed with Gentian roots.
  • In rare cases, tachycardia (heart palpitations) and pruritus have been reported. 
  • Headaches.
  • Lavender might cause burping and skin reactions like itching and hives. 

How to take Kalms tablets?

To use Kalms tablets to help relieve symptoms associated with stress such as mild anxiety and irritability or symptoms that are associated with menopause, it is important that you talk to your physician about the dosage. 

The adult recommended dosage will be mentioned on the instructions leaflet depending on the type of Kalms tablets you are taking in. The recommended dose for adults and the elderly is 2 tablets 30 to 60 minutes before bedtime.

It is not recommended for children under the age of 12 years old since there is limited research on how kalms impact younger individuals. 

The oral drug is for short term use only and must not be taken as a lifelong treatment to aid with stress, insomnia, and anxiety. 

The tablets should be swallowed whole with water or other liquid

This medicine should be taken for 2-4 weeks continuously. The maximum daily dose is 6 tablets and one should not take more than six a day/

Who shouldn’t use Kalms?

Some people who have the following conditions should not use Kalms and should consult a doctor for an alternative medication to help treat their ailments. 

  • People with any type of infection (including HIV, malaria, or tuberculosis);
  • Should not be used to treat anxiety or depression;
  • People with asthma or allergies;
  • Cancer Patients;
  • Should not be used to treat erectile dysfunction
  • People with Heartburn or gastroesophageal reflux disease (GERD);
  • With high blood pressure, high cholesterol, or a heart condition;
  • migraine headaches
  • psoriasis, rheumatoid arthritis, or other autoimmune disorders;
  • People who have a medical history of epilepsy and Seizures.


This blog post has explored the question of whether you can take Kalms with other medications.

We have also briefly discussed what Kalms is, what it is used for, the different kinds of kalms and the key ingredients used in Kalms and it’s side effects, as well as other risks and precautions when taking the drug. 

Faq related to Can you take Kalms with other medications?

Do Kalms contain alcohol?

Yes. Kalms tablets do contain the alcohol Ethanol at 60% as a solvent but not as an active ingredient. 

Do Kalms tablets work for anxiety?

Yes, the effects of the key ingredient valerian in Kalms can help people feel calmer and less anxious but it must not be used as a replacement for approved pharmaceutical treatment for cancers. 

Can you overdose on valerian?

Case studies on the possible overdose on Valerian root found that overdosing on valerian root is possible but not lethal and only presents mild symptoms that resolve itself within a few hours. 

Can I drink alcohol with valerian root?

Because of the key ingredients of Valerian root, hop strobiles which are flowers of the hop plant Humulus lupulus, and Gentian root extracts, manufactures of the Kalms Tablet do not recommend using Alcohol with the drug as it increases the risk of increased drowsiness when it is used together. 

When should you not take kalms?

You should not take Kalms in the following scenario:

If you are under 12 years old. 

If you are pregnant, trying to get pregnant, or breastfeeding. 

If you have missed a dose and are close to the next dose, wait for the next dose to avoid double dosing. 

If you are about to drive

If you are drinking alcohol

If you are about to use heavy machinery.


Kalms Day Tablets. Click2Pharmacy. Retrieved on 21st January 2022.

Macmillan.A. Herbal Supplements May Be Dangerous When You Take Certain Prescription Drugs. Time. 24th January 2018. Retrieved on 21st January 2022.

Kelber, O., Nieber, K., & Kraft, K. (2014). Valerian: no evidence for clinically relevant interactions. Evidence-based complementary and alternative medicine: eCAM, 2014.

Hadley S, Petry JJ. Valerian. Am Fam Physician. 2003 Apr 15;67(8):1755-8. PMID: 12725454.

Possible Interactions with: Valerian. St.Lukes. Retrieved on 21st January 2022.

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