Do kalms work for treating depression?

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This blog post will explore whether Kalms can be used to treat depression symptoms. 

We will also briefly discuss what Kalms is, what it is used for, recommendations for use and precautions as well as side effects. 

Do kalms work for treating depression?

There is little to no information related to Kalms being used to treat and manage symptoms of depression.

However, Kalms is used to treat stress related issues and problems including sleep and anxiety but there is a gap in literature that explores the use of Kalms for depression. 

So if depression is a result of stress and anxiety, Kalms can be used to cope and manage these comorbid symptoms.

While the drug itself, and the company that makes the drug does not make any claims to its effectiveness in treating depression, there have been various studies that explore the use of the key ingredients and its effects of depression and anxiety. 

The first key ingredient that is used in Kalms is Humulus lupulus which is a herb that is generally known to be a key ingredient in helping manage anxiety and mood disorder symptoms. 

To understand the effectiveness of this herb on self-reported experiences of depression, a study was conducted on young adults- 36 college students who have reported at least mind depression, stress, and anxiety. 

The students were given the drug for a 4-week intervention period with no significant changes in body weight nor in the individuals circulating levels of cortisol in both the group that was administered the herb and the group that was given the placebo. 

The researchers found that on self-assessment, there were significant changes in the participants anxiety, depression, and stress scores. 

The researchers concluded that in these healthy participants who have reported mild levels of depression, stress, and anxiety, the daily administration of kalms were seen to significantly reduce symptoms when the drug was taken for at least four weeks. 

However, one has to mention that while there is a positive effect of the drug on anxiety, stress, and depression as shown by this particular study, one has to understand that the effect of this herb on depression alone cannot be alienated and the findings cannot be generalised. 

In a study published in 2021 that explored the effects of Valerian root on Sleep Quality, Depression, and State Anxiety on 39 patients undergoing Hemodialysis, the results indicated that Valerian root does have some effect.

In the study, the participants were divided into two groups where the first group was administered valerian root before sleep and the second group was given a placebo at the same time for one month. 

Both groups were assessed related to their quality of sleep, activity, and depression using various inventories and indexes. After a month, it was found that Valerian root “… significantly improved sleep quality, the symptoms of state anxiety, and depression in HD patients.” (Tammadon et al, 2021).

While this particular study notes that there is potential use for the ingredients in Kalms to treat depression, other experts fear that there will be adverse side effects that can worsen depression in some individuals if it is taken without expert advice by a medical professional.

In a separate study that examined the effect of Gentian root, another ingredient of Kalms, as an antidepressant on male rates, the researchers concluded that it might have some antidepressant impact and activity on the rats system. 

The researchers noted that after the rats were administered with the herb, the previously decreased serotonin and noradrenaline levels within the hippocampus of the brain of the test subjects significantly increased. 

While this study shows that there is potential for the herb to be effective in terms of antidepressant potential, this study has only been done on non-human subjects which makes the impact of the herb on human beings still unknown. 

Even though the separate key ingredients used in kalms have been studied to some extent and findings indicate that there is some effect of each herb on depression one cannot certainly say that the drug itself can be used to treat depression since there is a gap in literature that studies the effect of the drug on depression symptoms. 

What are Kalms tablets?

Kalms Tablets are traditional natural drugs designed for relief of signs associated with:

  • Stress (e.g mild anxiety, worry, irritability)
  • Menopause (e.g flushings, worry, wakefulness, cold sweats)
  • Sleeping problems, promoting natural sleep

Kalms tablets are made of hop strobiles which are flowers of the hop plant Humulus lupulus, and extracts of Valerian root and Gentian root.

It is important that before you use the tables to ask your doctor or pharmacist if you can take Kalms tablets when taking other prescription medicines or medicines without a prescription.

How to take Kalms tablets?

To use Kalms tablets to help relieve symptoms associated with stress such as mild anxiety and irritability or symptoms that are associated with menopause, it is important that you talk to your physician about the dosage. 

The adult recommended dosage will be mentioned on the instructions leaflet depending on the type of Kalms tablets you are taking in. The recommended dose for adults and the elderly is 2 tablets 30 to 60 minutes before bedtime.

It is not recommended for children under the age of 12 years old.

What are some recommendations for taking Kalms tablets?

Some recommendations given for the use of Kalms tablets include:

  • The oral drug is for short term use only and must not be taken as a lifelong treatment to aid with stress, insomnia, and anxiety. 
  • The tablets should be swallowed whole with water or other liquid
  •  The use of this product in children or adolescents under 12 years of age is not recommended because research data is not sufficient.
  • This medicine should be taken for 2-4 weeks continuously 
  • The maximum daily dose is 6 tablets, Do not exceed the stated dose. 

Who shouldn’t use Kalms?

Some people who have the following conditions should not use Kalms and should consult a doctor for an alternative medication to help treat their ailments. 

  • People with any type of infection (including HIV, malaria, or tuberculosis);
  • Should not be used to treat anxiety or depression;
  • People with asthma or allergies;
  • Cancer Patients;
  • Should not be used to treat erectile dysfunction
  • People with Heartburn or gastroesophageal reflux disease (GERD);
  • With high blood pressure, high cholesterol, or a heart condition;
  • migraine headaches
  • psoriasis, rheumatoid arthritis, or other autoimmune disorders;
  • People who have a medical history of epilepsy and Seizures.

What are the side effects of Kalms?

Even though this is considered a natural and herbal remedy. Valerian root and other herbal remedies can cause side effects. 

While not everyone will experience the same side effects or effects of the medication, it is important to be aware of the reactions it might cause. 

Side effects include:

  • Gastrointestinal effects such as nausea and stomach cramps.
  • Gastrointestinal disorders have been observed with Gentian roots.
  • In rare cases, tachycardia (heart palpitations) and pruritus have been reported. 
  • Headaches.
  • Lavender might cause burping and skin reactions like itching and hives. 


This blog post has explored whether Kalms can be used to treat depression symptoms. 

We have also briefly discussed what Kalms is, what it is used for, recommendations for use and precautions as well as side effects. 

Faq related to Do kalms work for treating depression?

Do kalms do anything?

Kalms Tablets are traditional natural drugs designed for relief of signs associated with:

  • Stress (e.g mild anxiety, worry, irritability)
  • Menopause (e.g flushings, worry, wakefulness, cold sweats)
  • Sleeping problems, promoting natural sleep

How long does it take for kalms to start working?

On an average, Kalms takes at least seven to 10 days for the product to have the desired effect and aid in better sleep and lower levels of stress. 

Do kalms work for anxiety?

The calming effect of Kalms might be helpful in aiding individuals to cope with symptoms of anxiety such as irregular or distrubed sleep; however, it should not be used as a standalone drug treatment for anxiety. 

Can I take 2 kalms one a night?

It is advisable that you take only one Kalms tablet per night. However, if you take more Kalms Night One-A-Night than you should Seek medical advice in the event of an overdose. 

Do kalms day make you sleepy?

Kalms Day tablets may make you feel sleepy because it helps to make an individual clamer and drowsy thus it is advisable that people do not drive or use machines after taking Kalms.  The sedative effects of this medicine may be increased by alcohol. Therefore alcohol should be avoided whilst taking this medicine.

Are kalms dangerous?

Kalms is considered safe, however, it can potentially be dangerous if you are allergic to any of the components, or if you are pregnant or breastfeeding.

It is also not advisable to be used on children below the age of 12 or people with heart conditions. Heartburn, allergies, and infections. 

Is it OK to take kalms everyday?

Kalms is considered to be fairly safe, so it can be taken every day. However, kalms is not  a long term solution, so if you experience how the symptoms get worse, consult with your doctor.


Kalms Day Tablets. Click2Pharmacy. Retrieved on 5th January 2022.

Tammadon MR, Nobahar M, Hydaria-Naeini Z, Ebrahimian A, Ghorbani R, Vafaei AA. The Effects of Valerian on Sleep Quality, Depression, and State Anxiety in Hemodialysis Patients: A Randomised, Double-blind, Crossover Clinical Trial. Oman Med J. 2021;36(2):e255. Published 2021 Mar 31. doi:10.5001/omj.2021.56

Panoff.L. 4 Potential Side Effects of Valerian Root. Healthline. Retrieved on 5th January 2022.

Berk A, Yılmaz İ, Abacıoğlu N, Kaymaz MB, Karaaslan MG, Kuyumcu Savan E. Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress. Libyan J Med. 2020;15(1):1725991. doi:10.1080/19932820.2020.1725991

Kyrou I, Christou A, Panagiotakos D, Stefanaki C, Skenderi K, Katsana K, Tsigos C. Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study. Hormones (Athens). 2017 Apr;16(2):171-180. doi: 10.14310/horm.2002.1738. PMID: 28742505.

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