Sertraline reviews (Does it help?)

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In this brief article, we will be discussing the reviews of Sertraline by users who use the drug for treating their mental health conditions. 

We will also discuss what Sertraline is, what research says about it’s efficacy, its usages, side effects, and it’s usage. 

What are the reviews for Sertraline?

According to user reviews of Sertraline on various sites such as, Sertraline has an average rating of 7.2 out of 10 while on the site of WebMd, it has an average rating of 3.8 out of five. 

The drug has more positive reviews than negatives with users using this pharmacological treatment for conditions like depression, anxiety, stress, premenstrual dysmorphic disorder, panic disorder, social anxiety disorder, OCD etc. 

The reviews of Sertraline differ in feedback and rates depending on the application of the drug for various disorders with 63 % positive reviews out of 3,743 total reviews at drugs. Com. 

We will take a closer look at the reviews but before that let us look at what Sertraline is and its application.

What is Sertraline?

Sertraline or known by its brand name Zoloft, is a prescription drug usually in the form of an oral tablet that belongs to a group of drugs called SSRIs antidepressants. 

Sertraline, a Selective Serotonin Reuptake Inhibitor, helps the brain regulate neurochemicals and help balance the levels of these chemicals so as to help treat depression, panic, anxiety, or obsessive-compulsive symptoms and other mental health disorders caused by its lack of regulation and balance. 

Sertraline works by increasing the amount of serotonin in the brain by inhibiting it’s reuptake so as to create a balance of the neurochemicals in the brain to maintain mental health functioning. This can improve the symptoms of various disorders caused by the dysregulation of serotonin.

What are the uses of Sertraline?

Sertraline or Zoloft’s major label use is for the treatment of major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). However, it is also used for other off-label applications such as Anxiety, Stress, Bipolar, GAD, and also used to treat premenstrual dysphoric disorder.

This drug may also be used as part of a combination therapy- with other drugs which help treat mental disorders.

What is the efficacy of sertraline?

According to one of the initial systematic reviews of Sertraline for the therapeutic potential for depression and OCD, the clinical experience and application of the drug has been found to be significantly effective compared to the use of placebos in clinical populations. 

The drug has also been found to have similar efficacy with other antidepressants even observed to be marginally more effective than drugs like amitriptyline. The drug has also been recorded to recyde the risk of relapse in depression and also studied to have effective outcomes for the treatment of OCD. 

While the drug has various side effects, the review mentions that these side effects are usually mild and decreases in frequency with continued use and treatment and the review also suggests that these initial findings can put Sertraline as one of the best drugs for treating depression and other mental health disorders. 

What are the side effects of Sertraline?

Sertraline, like other medications, has various side effects and risks. These include:

Common side effects such as:

  • nausea, loss of appetite, diarrhea, and indigestion
  • change in sleep habits, including increased sleepiness and insomnia
  • increased sweating
  • sexual problems, including decreased sex drive and ejaculation failure
  • tremor or shaking
  • tiredness and fatigue
  • agitation

Serious side effects include:

  • Suicide attempts and ideation
  • Aggressive behavior
  • Worse depression
  • Anxiety or panic attacks
  • Agitation, restlessness
  • Trouble sleeping
  • hallucinations and delusions
  • loss of consciousness
  • seizures
  • coma
  • fast heart rate
  • muscle rigidity
  • Severe allergic reactions.
  • Abnormal bleeding
  • Low sodium levels. 
  • Changes in vision, including blurred and double vision

You should avoid the use of this drug if you:

  • have had an allergic reaction to sertraline 
  • have a heart problem 
  • have ever taken any other medicines for depression 
  • are trying to become pregnant, already pregnant or breastfeeding
  • have an eye problem called glaucoma 
  • have epilepsy or are having electroconvulsive treatment 
  • If you have diabetes

You have to discuss these risks and the side effects with your doctor thoroughly before you decide on the prescription as there are many alternatives that you can use for treatments- discussing with your doctor is very important.

How does one use Sertraline?

To take Sertraline, the best thing you can do is to follow your doctor’s instructions with precision and persevere in the treatment in spite of the various side effects you might experience, including alleviation of the symptoms of your mental disorder. 

If you are experiencing side effects, talking to your doctor immediately is an important step in getting yourself the right treatment. 

Ususa;;your doctor will prescribe the drug once a day,with or without food, at any time of the day as long as you stick to the same time everyday. 

If you have trouble sleeping, it is best to take the drug in the morning since one of the side effects of the drug is that it can make your insomnia worse or can cause insomnia. 

The usual dose of sertraline is 50mg a day in adults however it can be lower depending on the person’s body, condition, weightm, mass, and metabolism. Your doctor can start you at a lower dose and gradually increase it to a maximum of 200 mg per day. 

For children, the usual dose of sertraline is 25mg a day, but this may be increased to 50mg a day after a week. For teenagers, the usual dose is 50mg per day which can be increased as needed. 

In case you forget to take the dose, take the dose the next day at the same time and never take two doses at once or too close together to make up for the forgotten dose. 

Setting an alarm can be helpful to remind you of the dose in case you are forgetful, at times you might find yourself resisting the dosage because of the side effects which makes you forget or miss a few doses- in such cases, talking to your doctor about the side effects can be helpful.

If you suspect yourself of taking too much of the drug, call your doctor if you notice the following symptoms:

The amount of sertraline that can lead to an overdose varies from person to person.

  • being sick (vomiting)
  • shaking
  • feeling sleepy
  • dizziness
  • fast heart rate
  • fits or seizures

What are the reviews of Sertraline?

Let us look at some compiled reviews of the drug Sertraline also known as Zoloft and also some individual video reviews of the drug by various users who have been prescribed the drug for treating mental disorders.

User reviews of Sertraline on Drugs.Com

The user reviews of Sertraline on, details an average rating of 7.2 out of 10 for the drug with approximately 63% of positive reviews for the drug against 18% of negative reviews. 

The statistics show that the drug is used for various disorders such as Depression, Anxiety and Stress, Panic Disorder, Social Anxiety Disorder, Obsessive Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder, Post Traumatic Stress Disorder, Premenstrual Dysphoric Disorder, Postpartum Depression, Bipolar Disorder, Borderline Personality Disorder, Persistent Depressive Disorder, Dissociative Identity Disorder, Trichotillomania, Body Dysmorphic Disorder,Vulvodynia.

The drug’s average ratings for Premenstrual Dysmorphic disorder and postpartum depression was highest  (above 8) followed by OCD, GAD. However, the drug’s rating for depression or MDD were an average of 6.5 out of 10.

Some of the top reviews of Sertraline are:

  • Saved_MyLife uses Zoloft (sertraline) for Depression and wrote, “I’m 36 and I’ve dealt with depression my entire life. I was also irritable. It would come, hit me hard, and then go away. I thought diets, sleep etc could help me. They would only at first. I gave Lexapro a try, my first medication ever. It helped some and I wanted to “settle” with Lexapro because at least my depression was at bay. Two years ago I started Zoloft and it literally saved my life, marriage, memories with my kids, saved me from me. I truly didn’t know what normal life was like until I started Zoloft. It hasn’t changed me, it helped me be the true, happy me that would show up periodically. All those “organic” ways might help some people. Just don’t think “big pharma” can’t help you, like I did before I tried meds. I never ever ever thought I would be saying that. For two years now I’ve been alive, I’ve run my business like never before; I’m patient with my kids, my wife, my family. I hope this review helps someone out there who is just like I was.”
  • Fearisachoice uses it For Anxiety and Stress: “I would literally re read the high rated reviews of sertraline every day. I had them saved on my phone. Reading them whilst I cried, thoughts racing, heart hammering, I was depending on people’s experiences for my life. Sertraline is not easy initially. It has literally saved my life. My brain is quiet. I haven’t had any panic attacks. I am so so so happy and positive and amazed at what this tablet can do. For you who is going through the tough bits- please have hope that it is worth it. STICK WITH IT. Because I was in the same position as you. I was SO worried the tablets were not working, but actually they were. You are so brave and strong. I know it doesn’t feel like it but you are. Don’t give up because believe me whilst I write this I can remember myself thinking that I was going to. You are going to be OK. It is all normal to feel worse before you feel better. So unbelievably better. I can now be a friend, work colleague, daughter, wife and dog mum. Sertraline is incredible. A true life saver.”
  • Patricia uses it For Anxiety and Stress: “Read this! I have had anxiety my whole life But then I had my first baby and it all escalated. I couldn’t sleep. I could take a big dose of oxazepam and still be awake. After 14 days of constant fear and panic attacks I said: I am not ok. I needed to get away from the baby. So I went to my mom. I started sertraline and the first 5 weeks were terrible. I could only lay in bed with a HR of 100/m, feeling anxious and didn’t eat for 2 weeks. After 5 Weeks I wanted to stop because I had never felt so horrible in my life. 2 days later it happened. I woke up and I didn’t feel that bad anymore. And the next day again. And so on. January was the worst month of my life, by far, but now everything is different. I can enjoy my daughter and sertraline did that. So again, for whatever reason you are here, sometimes we cannot do this on our own. You are not weak to start medication. And please, continue the first few weeks. They are horrible. But come back and read this story again. Trust the process.”

User reviews of Sertraline on WebMD

The user reviews on WebMD have given Sertraline an average 3.8 out of 5 for approximately 500 + reviews. The drug has been given an average rating of 3.8 for effectiveness, 4.5 for ease of use, and 3.5 for satisfaction. 

Some of the top reviews for this drug include:

  • Anonymous, 25-34, Female, On medication for 5 to less than 10 years writes: “This medication saved my life. After suffering severe PTSD after trauma/sexual assault as a child and hitting rock bottom this medication really helped through hardest time of my life, it took the edge off when times got too hard for me. Highly recommended, the first few weeks have awful horrible side effects but please be patient with it.”
  • Sn74, a teenage, 13-18 year old, Male writes “I have been taking sertraline for 10 months now. Firstly, I have had times I missed doses for financial reasons, i could go about 2-3 days for the withdrawal to kick in. Withdrawal from sert is not a fun experience, with things like dizziness and anxiety, with the loss of balance. Aside from those times, my side effects were moderate, having things like forgetfulness and drowsiness being the most common. Some other side effects i have noticed are things like; a very low tolerance to marijuana and alcohol, low sex drive, and occasionally high depressive states that come and go quickly. Overall I’d say 6.5/10 in treating my depression, 5/10 in the number of side effects, and overall I would give the drug a 6.8 overall.”
  • Anonymous, 19-24, Female On medication for 6 months to less than 1 year writes. “I have been taking this medication since July and I have seen a major change in my mood and energy levels. I’m usually in a great mood and always up doing something. My only issue would be of a sexual nature. I’ve been in a relationship for a little over 3 years and I have never had trouble getting an orgasm until I got on the medication. It’s very frustrating. That, however, would be my only complaint.”
  • Theo, a 55-64 Male On medication for 10 years or more writes: “I have taken this for 15 years, The things that I used to care about no longer worry me. no sexual side effects, i recommend this for people who want to take the edge off! Side effect: on missing a dose I feel my head is a whooshing sound and it makes me a little lightheaded. so I don’t miss doses if I can help it.”

Some individual video reviews of the drug include:

  • Marcello LaGreca on his youtube channel who was on Zoloft for 2.5 years. In his video he discusses his experiences with Zoloft, how an SSRI works, and side effects. He also provides a detailed review of the drug in his treatment for his mental disorder.
  • Bethan Louise also discusses her journey with the drug as she explores the effects it has had on her treatment and her own life. In her video she covers her anxiety and depression journey towards treatment and her own thoughts about the drug. 
  • Emma Howorth in her own video on her journey with Zoloft/ Sertraline writes about how her depression impacted her life and how her treatment with the drug has affected her and the symptoms she has been experiencing. She gives a detailed review about the drug and how it’s side effects affected her, and how the drug worked in her case.


In this brief article, we discussed the reviews of Sertraline by users who use the drug for treating their mental health conditions. 

We also discussed what Sertraline is, what research says about it’s efficacy, its usages, side effects, and it’s usage. 


Murdoch D, McTavish D. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24. doi: 10.2165/00003495-199244040-00007. PMID: 1281075.

Sertraline. NHS. 12 December 2018. Retrieved on 25th November 2021.

Sertraline, Oral Tablet. Healthline. 27th July 2021. Retrieved on 25th November 2021.

User Reviews for Sertraline. Retrieved on 25th november 2021.

User Reviews for Sertraline Oral. WebMD. Retrieved on 25th november 2021.

FAQ related to Sertraline reviews

How did sertraline make you feel?

Sertraline can help you jump start your mood, make you less anxious, and sleep better.Ut can also help you reduce your anxiety, improve energy, motivation, and overall improvement of your mood. 

How does sertraline make you feel at first?

In the first few days of you taking the drug you might deal with it’s side effects, make you feel drowsy and also might impact your thoughts, dreams, and also sleep and appetite. These initial symptoms and side effects will diminish gradually.

What is the most common side effect of sertraline?

Commonly reported side effects of sertraline include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia.

How do I know sertraline is working?

To know that Sertraline is working, your sleep, energy, or appetite may show some improvement within the first 1-2 weeks along with other physical improvem,emts. Depressed mood and apathy or anhedonia related symptoms might take 6-8 weeks to fully improve. 

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